# Estimating design-comparable standardized mean differences with scdhlm

#### 2020-11-30

The scdhlm package (Pustejovsky, Chen, & Hamilton, 2020) provides several methods for estimating design-comparable standardized mean differences (SMDs) based on data from a single-case design. In principle, a design-comparable SMD is in the same metric as the SMD from a simple, between-groups randomized experiment performed on a comparable sample and with comparable outcome measures. Hedges, Pustejovsky, and Shadish (2012) proposed methods for estimating design-comparable SMDs based on data from an ABAB design (and, more generally, treatment reversal designs with an arbitrary number of phases). Hedges, Pustejovsky, and Shadish (2013) extended the methods to handle data from multiple baseline designs. In both cases, the proposed estimation methods are premised on a simple model for the data, which assumed that the outcome process is stable over time (lacking time trends) and that the treatment effect is constant across cases. Pustejovsky, Hedges, and Shadish (2014) proposed an approach to defining and estimating design-comparable SMDs under a more general model, which can allow for time trends and between-case variation in treatment effects and time trends.

In the scdhlm package, the original estimation methods proposed for the ABAB design and multiple baseline design are implemented in the effect_size_ABk and effect_size_MB functions, respectively. Both of these functions take the raw data as input and produce as output an effect size estimate, along with accompanying standard error and some other auxiliary information. Thus, there is no distinction between estimating the model and estimating the effect size. In contrast, the more general methods proposed in Pustejovsky, Hedges, and Shadish (2014) entail two steps: first, estimating a hierarchical model for the data; and second, estimating a design-comparable effect size based on the fitted model. The first step is accomplished using the function lme from the package nlme by Pinheiro, Bates, DebRoy, and Sarkar (2015). The second step is accomplished using the function g_mlm from the scdhlm package. This vignette demonstrates how to use all of these functions to estimate design-comparable standardized mean difference effect sizes. The R code presented below can be used to replicate the examples found in the papers that proposed the methods. To begin, the user must load the package:

library(scdhlm)

## Lambert, Cartledge, Heward, & Lo (2006)

Lambert, Cartledge, Heward, and Lo (2006) tested the effect of using response cards (compared to single-student responding) during math lessons in two fourth-grade classrooms. The investigators collected data on rates of disruptive behavior for nine focal students, using an ABAB design. This example is discussed in Hedges, Pustejovsky, and Shadish (2012), who selected it because the design was close to balanced and used a relatively large number of cases. Their calculations can be replicated using the effect_size_ABk function. To use this function, the user must provide five pieces of data:

• the outcome variable,
• a variable indicating the treatment condition,
• a variable listing the case on which the outcome was measured,
• a variable indicating the phase of treatment (i.e., each replication of a baseline and treatment condition), and
• a variable listing the session number.

In the Lambert dataset, these variables are called respectively outcome, treatment, case, phase, and time. Given these inputs, the design-comparable SMD is calculated as follows:

data(Lambert)

Lambert_ES <- effect_size_ABk(outcome = outcome, treatment = treatment,
id = case, phase = phase, time = time,
data = Lambert)

print(Lambert_ES, 5)
##                              est      se
## unadjusted effect size  -2.52460 0.20228
## adjusted effect size    -2.51307 0.20136
## degree of freedom      164.49227

The adjusted effect size estimate delta_hat is equal to -2.513; its variance V_delta_hat is equal to 0.041. A standard error for delta_hat can be calculated by taking the square root of V_delta_hat: sqrt(Lambert_ES$V_delta_hat) = 0.201. The effect size estimate is bias-corrected in a manner analogous to Hedges’ g correction for SMDs from a between-subjects design. The degrees of freedom nu are estimated based on a Satterthwaite-type approximation, which is equal to 164.5 in this example. A summary() method is included to return more detail about the model parameter estimates and effect size estimates: summary(Lambert_ES) ## est se ## within-case variance 4.534 ## sample variance 4.674 ## intra-class correlation 0.030 ## auto-correlation 0.225 ## numerator of effect size estimate -5.458 ## unadjusted effect size -2.525 0.202 ## adjusted effect size -2.513 0.201 ## degree of freedom 164.492 ## scalar constant 0.145 By default, the effect_size_ABk function calculates an estimate of the first-order autocorrelation in the outcome series (stored in the entry phi) and an estimate of the intra-class correlation, i.e., the ratio of the between-case variance in the outcome to the total cross-sectional variance in the outcome (the intra-class correlation estimate is stored in the entry rho). Optionally, the user can specify their own estimates of these parameters as inputs to the function. In this example, the auto-correlation estimate was 0.225. The following code examines the sensitivity of the results to values of the auto-correlation that are larger and smaller than the default estimate of 0.225. Lambert_ES2 <- effect_size_ABk(outcome = outcome, treatment = treatment, id = case, phase = phase, time = time, data = Lambert, phi = 0.10) print(Lambert_ES2, digits = 5) ## est se ## unadjusted effect size -2.52460 0.19376 ## adjusted effect size -2.51265 0.19285 ## degree of freedom 158.73064 Lambert_ES3 <- effect_size_ABk(outcome = outcome, treatment = treatment, id = case, phase = phase, time = time, data = Lambert, phi = 0.35) print(Lambert_ES3, digits = 5) ## est se ## unadjusted effect size -2.52460 0.21697 ## adjusted effect size -2.51217 0.21591 ## degree of freedom 152.57482 The estimated auto-correlation has only a trivial effect on the effect size estimate and a minor effect on its estimated variance. ## Anglesea, Hoch, & Taylor (2008) Anglesea, Hoch, and Taylor (2008) used an ABAB design to test the effect of using a pager prompt to reduce the rapid eating of three teenage boys with autism. The primary outcome was a measure of how quickly each participant consumed one serving of a familiar food. This example is discussed in Hedges, Pustejovsky, and Shadish (2012), who used it to illustrate the calculation of the design-comparable SMD when based on the minimum required number of cases. Their calculations can be replicated using the following code: data(Anglesea) Anglesea_ES <- effect_size_ABk(outcome, condition, case, phase, session, data = Anglesea) Anglesea_ES ## est se ## unadjusted effect size 1.793 2.436 ## adjusted effect size 1.150 1.562 ## degree of freedom 2.340 Note that the standard error of the effect size estimate is quite large and the degrees of freedom corresponding to the denominator of the SMD estimate are very low. Both quantities are extreme due to the small number of cases used in this example. ## Saddler, Behforooz, & Asaro (2008) Saddler, Behforooz, and Asaro (2008) used a multiple baseline design to investigate the effect of an instructional technique on the writing of fourth grade students. The investigators assessed the intervention’s effect on measures of writing quality, sentence complexity, and use of target constructions. Design-comparable SMDs can be estimated based on these data using the effect_size_MB function. The syntax for this function is similar to that of the effect_size_ABk function, but does not require the user to input information about the phase of the design (because in the multiple baseline design, phase exactly corresponds to treatment condition). The following code replicates the calculations reported in Hedges, Pustejovsky, and Shadish (2013): data(Saddler) quality_ES <- effect_size_MB(outcome, treatment, case, time, data = subset(Saddler, measure=="writing quality")) complexity_ES <- effect_size_MB(outcome, treatment, case, time , data = subset(Saddler, measure=="T-unit length")) construction_ES <- effect_size_MB(outcome, treatment, case, time, data = subset(Saddler, measure=="number of constructions")) data.frame( quality = unlist(quality_ES), complexity = unlist(complexity_ES), construction = unlist(construction_ES) )[c("delta_hat","V_delta_hat","nu","phi","rho"),] ## quality complexity construction ## delta_hat 1.96307272 0.78540043 0.74755356 ## V_delta_hat 0.33491289 0.08023320 0.07847359 ## nu 8.91814603 9.60204004 7.57981360 ## phi 0.09965017 -0.07542229 -0.11159420 ## rho 0.63321198 0.61453091 0.73123744 For multiple baseline designs, an alternative to using the effect_size_MB function is to estimate a hierarchical linear model for the data and then use the g_mlm function. The two alternative approaches differ in how the model parameters and effect size are estimated. Pustejovsky, Hedges, and Shadish (2014) found that the latter approach (based on a hierarchical linear model) has comparable mean-squared error to the former approach, while producing better estimates of the variance of the effect size. The latter approach is implemented in two steps, which we will demonstrate using the writing quality measure. First, we estimate the hierarchical model with an AR(1) within-case error structure using the lme function: quality_RML <- lme(fixed = outcome ~ treatment, random = ~ 1 | case, correlation = corAR1(0, ~ time | case), data = subset(Saddler, measure=="writing quality")) summary(quality_RML) ## Linear mixed-effects model fit by REML ## Data: subset(Saddler, measure == "writing quality") ## AIC BIC logLik ## 97.31383 105.6316 -43.65692 ## ## Random effects: ## Formula: ~1 | case ## (Intercept) Residual ## StdDev: 0.6621631 0.6656806 ## ## Correlation Structure: ARMA(1,0) ## Formula: ~time | case ## Parameter estimate(s): ## Phi1 ## 0.3819756 ## Fixed effects: outcome ~ treatment ## Value Std.Error DF t-value p-value ## (Intercept) 2.437206 0.3187517 34 7.646094 0 ## treatmenttreatment 2.181029 0.2340101 34 9.320237 0 ## Correlation: ## (Intr) ## treatmenttreatment -0.308 ## ## Standardized Within-Group Residuals: ## Min Q1 Med Q3 Max ## -1.4700055 -0.4627404 -0.1907942 0.4286209 1.8063844 ## ## Number of Observations: 41 ## Number of Groups: 6 The summary of the fitted model displays estimates of the component parameters, including the within-case and between-case standard deviations, auto-correlation, and (unstandardized) treatment effect estimate. The next step is to combine these estimated components into an effect size estimate using the g_mlm function. This function takes the fitted lme model object as input, followed by the vectors p_const and r_const, which specify the components of the fixed effects and variance estimates that are to be used in constructing the design-comparable SMD. For details on how to choose these constants, see Pustejovsky, Hedges, and Shadish (2014). In this example: quality_ES_RML <- g_mlm(quality_RML, p_const = c(0,1), r_const = c(1,0,1), returnModel = TRUE) summary(quality_ES_RML) ## est se ## Tau.case.case.var((Intercept)) 0.438 0.357 ## cor_params 0.382 0.230 ## sigma_sq 0.443 0.154 ## total variance 0.882 0.360 ## (Intercept) 2.437 0.319 ## treatmenttreatment 2.181 0.234 ## treatment effect at a specified time 2.181 0.234 ## unadjusted effect size 2.323 0.595 ## adjusted effect size 2.174 0.557 ## degree of freedom 11.963 ## constant kappa 0.249 ## logLik -43.657 The adjusted SMD effect size is estimated as g_AB = 2.174; its standard error is SE_g_AB = 0.557; the estimated auto-correlation is phi = 0.382; and the estimated degrees of freedom is nu = 12. In this example, the RML effect size estimate is about 10% larger than the estimate from effect_size_MB, with a slightly smaller variance estimate. The RML estimate of the auto-correlation is substantially higher than before, but effect_size_MB uses a moment estimator that is known to be biased towards zero and that does not perform well when outcomes are intermittently missing for some sessions (as is the case here). ## Laski, Charlop, & Schreibman (1988) Laski, Charlop, and Schreibman (1988) used a multiple baseline across individuals to evaluate the effect of a training program for parents on the speech production of their autistic children, as measured using a partial interval recording procedure. The design included eight children; one child was measured separately with each parent; for purposes of simplicity, and following Hedges, Pustejovsky, and Shadish (2013), only the measurements taken with the mother are included in the analysis. The following code compares the estimates of the design-comparable SMD effect size based on the Hedges, Pustejovsky, and Shadish (2013) approach (using the effect_size_MB function) to the estimates based on the hierarchical linear modeling approach described in Pustejovsky, Hedges, and Shadish (2014) (using the g_mlm function). data(Laski) # Hedges, Pustejovsky, & Shadish (2013) Laski_ES_HPS <- effect_size_MB(outcome, treatment, case, time, data= Laski) # Pustejovsky, Hedges, & Shadish (2014) Laski_RML <- lme(fixed = outcome ~ treatment, random = ~ 1 | case, correlation = corAR1(0, ~ time | case), data = Laski) summary(Laski_RML) ## Linear mixed-effects model fit by REML ## Data: Laski ## AIC BIC logLik ## 1048.285 1062.466 -519.1424 ## ## Random effects: ## Formula: ~1 | case ## (Intercept) Residual ## StdDev: 15.68278 13.8842 ## ## Correlation Structure: AR(1) ## Formula: ~time | case ## Parameter estimate(s): ## Phi ## 0.252769 ## Fixed effects: outcome ~ treatment ## Value Std.Error DF t-value p-value ## (Intercept) 39.07612 5.989138 119 6.524498 0 ## treatmenttreatment 30.68366 2.995972 119 10.241637 0 ## Correlation: ## (Intr) ## treatmenttreatment -0.272 ## ## Standardized Within-Group Residuals: ## Min Q1 Med Q3 Max ## -2.72642154 -0.69387388 0.01454473 0.69861200 2.14528141 ## ## Number of Observations: 128 ## Number of Groups: 8 Laski_ES_RML <- g_mlm(Laski_RML, p_const = c(0,1), r_const = c(1,0,1)) # compare the estimates data.frame( HPS = with(Laski_ES_HPS, c(SMD = delta_hat, SE = sqrt(V_delta_hat), phi = phi, rho = rho, nu = nu)), RML = with(Laski_ES_RML, c(g_AB, SE_g_AB, theta$cor_params,
theta$Tau$case / (theta$Tau$case + theta\$sigma_sq), nu))
)
##             HPS        RML
## SMD  1.38838504  1.4048872
## SE   0.31701943  0.2863249
## phi  0.01652579  0.2527690
## rho  0.69396648  0.5606064
## nu  13.10041496 18.5524061

As in the Saddler example, both methods produce very similar SMD estimates and variance estimates. The RML estimate of auto-correlation is substantially higher than the HPS estimate, while the intra-class correlation estimate is somewhat lower; in combination, these differences lead to larger degrees of freedom.

An advantage of the RML approach is that it is readily extended to more complex models. The above analysis was based on the assumption that the treatment effect is constant across cases. This assumption can be removed by fitting a model that includes a random treatment effect for each case:

Laski_RML2 <- lme(fixed = outcome ~ treatment,
random = ~ treatment | case,
correlation = corAR1(0, ~ time | case),
summary(Laski_RML2)
## Linear mixed-effects model fit by REML
##        AIC      BIC    logLik
##   1036.014 1055.868 -511.0069
##
## Random effects:
##  Formula: ~treatment | case
##  Structure: General positive-definite, Log-Cholesky parametrization
##                    StdDev   Corr
## (Intercept)        21.79581 (Intr)
## treatmenttreatment 13.24108 -0.869
## Residual           11.94109
##
## Correlation Structure: AR(1)
##  Formula: ~time | case
##  Parameter estimate(s):
##        Phi
## 0.02267299
## Fixed effects: outcome ~ treatment
##                       Value Std.Error  DF  t-value p-value
## (Intercept)        38.45243  7.881197 119 4.879008       0
## treatmenttreatment 31.59161  5.178366 119 6.100691       0
##  Correlation:
##                    (Intr)
## treatmenttreatment -0.835
##
## Standardized Within-Group Residuals:
##         Min          Q1         Med          Q3         Max
## -3.12357773 -0.50574784 -0.01605527  0.65004147  2.05388331
##
## Number of Observations: 128
## Number of Groups: 8
anova(Laski_RML, Laski_RML2)
##            Model df      AIC      BIC    logLik   Test  L.Ratio p-value
## Laski_RML      1  5 1048.285 1062.466 -519.1424
## Laski_RML2     2  7 1036.014 1055.868 -511.0069 1 vs 2 16.27091   3e-04

The fit of the two models can be compared using a likelihood ratio test, which rejects the model with a constant treatment effect. The second model, which allows the treatment effect to vary, is to be preferred. The following code estimates a design-comparable SMD based on the better-fitting model.

Laski_ES_RML2 <- g_mlm(Laski_RML2, p_const = c(0,1), r_const = c(1,0,0,0,1))
Laski_ES_RML2
##                           est    se
## unadjusted effect size  1.271 0.386
## adjusted effect size    1.181 0.358
## degree of freedom      10.776

The adjusted effect size estimate that is 16% smaller than the estimate from the simpler model; with a standard error that is 25% larger. The difference between the two models is due to a difference in between-case variance across phases not captured by the assumptions of the simpler model. The between-case variation in the outcome appears to be substantially larger in the baseline phase than in the treatment phase. Maintaining the constant treatment effect assumption constrains the between-case variance to be constant across phases, and so the between-case variance is estimated by pooling across both phases. The constant treatment effect assumption therefore leads to a smaller variance estimate than the estimate based on allowing the between-case variance to differ by phase.

## Schutte, Malouf, & Brown (2008)

Schutte, Malouf, and Brown (2008) evaluated the effect of an emotion-focused therapy program for adults with prolonged fatigue using a multiple baseline across individuals. The design included 13 adults who met clinical criteria for prolonged fatigue. Fatigue severity was measured weekly using a self-reported scale that ranged from 1 to 63. Following Pustejovsky, Hedges, and Shadish (2014), the data for participant 4 are excluded from the analysis because nearly all of the measurements for this case are at the upper extreme of the scale. The data for the remaining participants are plotted below.

library(ggplot2)

data(Schutte)

graph_SCD(case = case, phase = treatment,
session = week, outcome = fatigue,
design = "MB", data = Schutte) +
facet_wrap(~ case, ncol = 3) +
theme(legend.position = "bottom")

Time trends are apparent in the outcome series, as are changes in slope in the treatment condition. In order to operationally define a design-comparable SMD effect sizes in a model that includes time trends and treatment-by-time interactions, one will need to choose a time point A at which the treatment would begin and a time point B at which outcomes would be measured, both in a hypothetical between-subjects design based on the same population of participants. Here, we take A = 2 and B = 9; centering time at week 9 simplifies the effect size calculations.

# time-point constants
A <- 2
B <- 9
# center at follow-up time

# create time-by-trt interaction
Schutte <-
preprocess_SCD(case = case, phase = treatment,
session = week, outcome = fatigue,
design = "MB", center = B, data = Schutte)

Having completed the data-cleaning process, three different models will be considered, again following the example from Pustejovsky, Hedges, and Shadish (2014).

## References

Anglesea, M. M., Hoch, H., & Taylor, B. A. (2008). Reducing rapid eating in teenagers with autism: Use of a pager prompt. Journal of Applied Behavior Analysis, 41(1), 107–111. doi: 10.1901/jaba.2008.41-107

Hedges, L. V., Pustejovsky, J. E., & Shadish, W. R. (2012). A standardized mean difference effect size for single case designs. Research Synthesis Methods, 3, 224-239. doi: 10.1002/jrsm.1052

Hedges, L. V., Pustejovsky, J. E., & Shadish, W. R. (2013). A standardized mean difference effect size for multiple baseline designs across individuals. Research Synthesis Methods, 4(4), 324-341. doi: 10.1002/jrsm.1086

Lambert, M. C., Cartledge, G., Heward, W. L., & Lo, Y. (2006). Effects of response cards on disruptive behavior and academic responding during math lessons by fourth-grade urban students. Journal of Positive Behavior Interventions, 8(2), 88-99.

Laski, K. E., Charlop, M. H., & Schreibman, L. (1988). Training parents to use the natural language paradigm to increase their autistic children’s speech. Journal of Applied Behavior Analysis, 21(4), 391–400.

Pinheiro J., Bates D., DebRoy S., Sarkar D. and R Core Team (2015). nlme: Linear and Nonlinear Mixed Effects Models. R package version 3.1-119. https://CRAN.R-project.org/package=nlme

Pustejovsky, J. E., Hedges, L. V., & Shadish, W. R. (2014). Design-comparable effect sizes in multiple baseline designs: A general modeling framework. Journal of Educational and Behavioral Statistics, 39(4), 211-227. doi: 10.3102/1076998614547577

Pustejovsky, J. E., Hamilton, B. J., & Chen, M. (2020). scdhlm: Estimating hierarchical linear models for single-case designs. R package version 0.3.2, https://jepusto.github.io/scdhlm/.

Saddler, B., Behforooz, B., & Asaro, K. (2008). The effects of sentence-combining instruction on the writing of fourth-grade students with writing difficulties. The Journal of Special Education, 42(2), 79–90. doi: 10.1177/0022466907310371

1. Note that the specification of the r_const argument here differs from the specification reported in Pustejovsky, Hedges, and Shadish (2014). The argument appears in a different order than reported in the article because of how the variance components are arranged in the g_mlm() function. To see the order of the variance components used by g_mlm(), use the extract_varcomp() function:

unlist(extract_varcomp(hlm2))
##      Tau.case.case.var((Intercept)) Tau.case.case.cov(week,(Intercept))
##                          95.7126979                          11.2090726
##             Tau.case.case.var(week)                          cor_params
##                           1.9938298                           0.3985953
##                            sigma_sq
##                          29.3943508

The order of parameter estimates appearing in the result is the same as assumed in g_mlm(). Thus, entries in r_const should correspond to the order of the parameter estimates appearing here.↩︎

2. Again, the specification of the r_const argument here differs from the specification reported in Pustejovsky, Hedges, and Shadish (2014). The entries in r_const should correspond to the order of the parameter estimates appearing in unlist(extract_varcomp(hlm3)).↩︎