Surrogate: Evaluation of Surrogate Endpoints in Clinical Trials

In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a biomarker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package 'Surrogate' allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's 7th Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.

Version: 0.1-68
Depends: MASS, msm
Imports: rgl, lattice, latticeExtra, survival, nlme, lme4, OrdinalLogisticBiplot, logistf, rms
Published: 2016-02-21
Author: Wim Van der Elst, Paul Meyvisch, Ariel Alonso, Hannah M. Ensor, Christopher J. Weir & Geert Molenberghs
Maintainer: Wim Van der Elst <Wim.vanderelst at>
BugReports: Wim Van der Elst <>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
Materials: NEWS
CRAN checks: Surrogate results


Reference manual: Surrogate.pdf
Package source: Surrogate_0.1-68.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Snow Leopard binaries: r-release: Surrogate_0.1-61.tgz, r-oldrel: Surrogate_0.1-5.tgz
OS X Mavericks binaries: r-release: Surrogate_0.1-68.tgz
Old sources: Surrogate archive