BIGDAWG: Case-Control Analysis of Multi-Allelic Loci

Data sets and functions for chi-squared Hardy-Weinberg and case-control association tests of highly polymorphic genetic data [e.g., human leukocyte antigen (HLA) data]. Performs association tests at multiple levels of polymorphism (haplotype, locus and HLA amino-acids) as described in Pappas DJ, Marin W, Hollenbach JA, Mack SJ. 2016. 'Bridging ImmunoGenomic Data Analysis Workflow Gaps (BIGDAWG): An integrated case-control analysis pipeline.' Human Immunology, article in press. Combines rare variants to a common class to account for sparse cells in tables as described by Hollenbach JA, Mack SJ, Thomson G, Gourraud PA. 'Analytical methods for disease association studies with immunogenetic data.' Methods Mol Biol. 2012; 882:245-66.

Version: 1.2.6
Depends: R (≥ 2.10)
Imports: XML, haplo.stats, parallel
Suggests: knitr
Published: 2016-02-20
Author: Derek Pappas, Steve Mack, Jill Hollenbach
Maintainer: Steve Mack <sjmack at>
License: GPL (≥ 3)
NeedsCompilation: no
Materials: NEWS
CRAN checks: BIGDAWG results


Reference manual: BIGDAWG.pdf
Vignettes: Using BIGDAWG
Package source: BIGDAWG_1.2.6.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Snow Leopard binaries: r-release: BIGDAWG_1.2.6.tgz, r-oldrel: not available
OS X Mavericks binaries: r-release: BIGDAWG_1.2.6.tgz
Old sources: BIGDAWG archive